Upcoming Events
Location:Belfast, UK
Time:September 26, 29, 2010
THEW session organized during this event: visit the meeting website.
Session: QT and Cardiac repolarization: Chairman: JP couderc
- Analyzing Thorough QT Study 1 & 2 in the Telemetric and Holter ECG
Warehouse (THEW) Using Hannover ECG system (HES®): A validation
study Antoun Khawaja*, Ratko Petrovic, Anton Safer, Tobias Baas, Olaf Doessel and Ronald Fischer. - Torsadogenic Drug-Induced Increased Short-term Variability of JT-area
Xiao Jie*, Blanca Rodriguez and Esther Pueyo - Electrocardiographic Markers Associated with Sotalol-induced Torsades
de Pointes Jean-Philippe Couderc*, Xiaojuan Xia, Stefan Kaab and Wojciech Zareba - Comparison of Three T-end Delineation Algorithms Based on Wavelet
Filterbank, Correlation and PCA Tobias Baas*, Franz Gravenhorst, Ronald Fischer, Antoun Khawaja and Olaf Dössel - QT/RR Coupling and Gender Differences. Josef Halamek*, Pavel Jurak, Jolana Lipoldova and Pavel Leinveber
- Modified Rectangular Finite Impulse Response Filter for Stabilization of QT
Measurement. Jing Wu, Jean-Philippe Couderc* and Xiaojuan Xia
IIn addition, the works from students whom have taken the THEW training program this past December will be presented in various poster session as well:
- A Comparison of IIR and Wavelet Filtering for Noise Reduction of the ECG
Jens Stampe Soerensen*, Lars Johannesen, Ulrik Silvanus Lerkevang Grove,
Kasper Lundhus, Jean-Philippe Couderc and Claus Graff - Analysis of Heart Rate Adaptation in Long-Term ECG Recordings Using
RR-Binning Lars Johannesen*, Ulrik Silvanus Lerkevang Grove, Jens Stampe Soerensen, Mick Lykkegaard Schmidt, Claus Graff and Jean-Philippe Couderc - Wavelet-based Algorithm for Delineation and Classification of ECG Waves
Lars Johannesen*, Ulrik Silvanus Lerkevang Grove, Jens Stampe Soerensen, Mick Lykkegaard Schmidt, Jean-Philippe Couderc and Claus Graff
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Location:Buesnos Ares, Argentina
Time:August 31, 2010
THEW Presentation during this event: visit the meeting website.
Couderc JP. The Telemetric and Holter ECG Warehouse Initiative (THEW): a Data Repository for the Design, Implementation and Validation of ECG-related Technologies.
Location:Hotel Albuquerque at Old Town
Albuquerque NM 87104
Time:April 21-25
Dr. JP couderc will present the Center for Quantitative Electrocardiography and Cardiac Safety during an afternoon session.
click here to download the session document.

Location: Arlington
Time: April 12-13th
Electrocardiographic Markers Associated with Sotalol-induced Torsades de Pointes. Presenter: JP Couderc, PhD
click here to download the slides of the presentation in pdf format.
Location: Hyatt Regency Bethesda, Bethesda, MD, USA
Time: Thursday 30th 5:00 to 6:00PM
THEW Update will be presented during the session chaired by Dr. Norman Stockbridge entitled Regulatory and Consortium Update.
click here to download the Meeting Agenda in pdf format.
10th Annual Phase I Clinical Trials Conference
Mon 09 Feb 2009 - Thu 12 Feb 2009 Olympia Conference Centre, London, United Kingdom.
Dr. Adel Nada, Medical Director
Clinical Pharmacology & Pharmacometrics
from Abbott Labs introduces the THEW initiative in his presentation entitled :"Managing Ventricular Arrhythmia in First-in-Man (FIM) Studies"
Integrating Pre-Clinical & Clinical Issues in Cardiac Safety: Translational Medicine Meets the Critical Path October 6th-7th
Bethesda, Maryland
Presenter: JP Couderc, PhD
“Computerized Method to Detect the QT Prolongation Induced by Moxifloxacin: Reporting the Results From Five-Drug-Safety Trials from the FDA Digital ECG Repository”
DIA – 3rd Annual Cardiac Safety Conference scheduled for December 4 – 5, 2008 taking place at the Hotel Hilton Barcelona in Spain.
December 4, 2008 from 11.00 – 12.30 CET
Session name: “Computerised Methodologies to Asses Cardiac Arrhythmia Vulnerability”. Chair: Boaz Mendezelevski, MD, Cardiac Safety Consultant, Cardiac Safety Consultants Ltd., UK.
Presenter: JP Couderc, PhD
Presentation of the THEW Initiative to the ESGCO Members.
The European Study Group on Cardiovascular Oscillations (ESGCO) was created during an Educational Training Course of the European Society of Cardiology in 1998 by Alberto Malliani, Tudor Griffith, Pontus Persson and Bernard Swynghedauw.
The goal of the Study Group is to promote basic research on cardiovascular oscillations, including heart rate and blood pressure variations, contractility changes, oscillations in microcirculation, calcium waves and ion movements.
Location: Parma , Italy
Presenter: JP Couderc, PhD
DIA: Evolution of Drug Development and Cardiac Repolarization.
In his presentation about the "Scientific Efforts to Further Define CV Safety". Dr. Stockbridge will introduce the THEW Initiative.
Location: Washington, USA
Presenter: Dr. Norman Stockbridge
Download the presentation:
New Biomarkers - The path to scientific and Regulatory Approval. B. Mendzelevski
Presentation of the THEW project and the recent progress related to its implementation.
Location Miami, FL
The Telemetric and
Holter Warehouse Project: - JP Couderc (URMC)
[12/16/2009]: The Director of the THEW interviewed by Technology Review published by the MIT: here.
[11/11/2009]: New Research Center to Focus on Cardiac Safety and Innovation in Pharmaceutical Industry Today: here.
[6/11/2009]: University of of Rochester and FDA Partner for ECG Database, Drug Discovery & Development Magazine. More info here
[5/6/2009] FDA website Existing Partnerships FDA’s Public-Private Partnership Program: THEW
[03/28/2009] Public and Private part- nership to help determine Clinical Biomarker Utility in Applied Clinical Trials online.com.>here
[7/26/2010] Members: Angel Medical System Inc. has joined the THEW initiative. Angel Medical Systems develops and markets cardiac devices that provide heart monitoring, alerting, and data collection. Their AngelMed Guardian system is an iimplantable cardiac monitoring and alerting system that is designed to warn cardiac patients of potentially life-threatening heart conditions.
[7/12/2010] The THEW quoted in a recent issue of the Journal of the American College of Cardiology. In a reply to a correspondence from Dr. Verrier and Nieminen on the role of T-wave alternans in hospital monitoring for torsades de pointes, Dr. Drew quoted the THEW as " a less expensive (than prospective clinical trials) and immediate available research strategy ... to validate ECG monitoring algorithms." JACC Vol. 56, No 3., 23010, 238-42.
[1/13/2010] Members: The Oxford University Computing Laboratory is the first new member for year 2010. At the heart of computing and related interdisciplinary activity at Oxford, this centre focuses on research in computer science, numerical analysis, computational biology, quantum computation, computational linguistics, and information systems. The Computational Biology Group also plays a key role in interdisciplinary initiatives across the University, including the EU FP7 projects euHeart and PreDiCT.
[05/27/2008]: "THEW Beyond QT working Group" releases an ECG marker submission form designed in collaboration with the FDA.
[12/13/2009]:The University of Rochester and the NHLBI enabled the creation of a "Center for Quantitative Electrocardiography and Cardiac Safety" (CES). Read more...
[05/27/2008] FDA: Dr. J. Woodcock (Director, CDER-FDA) and Dr. Norman Stockbridge (Director for the Division of Cardiovascular and Renal Products, CDER-FDA) signed a Letter of Agreement officially starting the partnership between the FDA and University of Rochester for the THEW initiative. More...



